Shengyuan Wang, Ph.D.

Education and Training

Areas of Expertise

Publications

• Wang, S., Wu, Z., Zhong, Z., Zhou, X., & Zang, C. (2025). Transcriptional condensates at super-enhancers mediate pH-dependent transcriptional control in innate immunity. bioRxiv, 2025-10. https://doi.org/10.1101/2025.10.29.685293
• Wang, S., Wang, Z., & Zang, C. (2025). Genomic clustering tendency of transcription factors reflects phase-separated transcriptional condensates at super-enhancers. Nucleic Acids Research, 53(3), gkaf015. https://doi.org/10.1093/nar/gkaf015
• Wang, S., Wang, Z., Atwood, G., Xu, Y., & Zang, C. (2025). CTCFDB: a systematic framework and comprehensive data resource for CTCF binding in the human genome. Cancer Research, 85(8_Supplement_1), 1074-1074. https://doi.org/10.1158/1538-7445.AM2025-1074.
• Ma, Z., Liu, M., Wang, S., Wang, S., & Zang, C. (2026). Differential analysis of image-based chromatin tracing data with Dory. bioRxiv, 2026-02. https://doi.org/10.64898/2026.02.19.706897
• Prajapati, S. C., Meydan, C., Neelamraju, Y., Wang, Z., Atwood, G., Paudel, B. B., Fan, H., Dunham, N., Dillon, R., Gandara, J. A., Lee, T., Sheridan, C., Wang, S., Zumbo, P., Becker, M. W., Bullinger, L., Carroll, M. P., D’Andrea, R. J., Levine, R. L., Mason, C., Melnick, A. M., Zang, C., Bekiranov, S., & Garrett-Bakelman, F. E. CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia. Neoplasia 74 (2026): 101293. https://doi.org/10.1016/j.neo.2026.101293
• Nguyen, Y., Sibley, L., Przanowski, P., Zhao, X. Y., Kovacs, M., Wang, S., ... & Zong, H (2024). Toxoplasma Gondii Infection Supports the Infiltration of T Cells into Brain Tumors. Journal of Neuroimmunology 393 (2024): 578402. https://doi.org/10.1016/j.jneuroim.2024.578402
• Wang, S., Wang, Z., Wang, Y. H., Li, H., Stukenburg, P. T., & Zang, C. (2024). Integration analysis of lncRNAs and R-loops in 3D genome organization and gene regulation in the cancer genome. Cancer Research, 84(6_Supplement), 7355-7355. https://doi.org/10.1158/1538-7445.AM2024-7355
• Al Awak, M.M., Wang, P., Wang, S., Tang, Y., Sun, Y.P. and Yang, L., 2017. Correlation of carbon dots' light-activated antimicrobial activities and fluorescence quantum yield. RSC advances, 7(48), pp.30177-30184. https://doi.org/10.1039/C7RA05397E
• Meziani, M.J., Dong, X., Zhu, L., Jones, L.P., LeCroy, G.E., Yang, F., Wang, S., Wang, P., Zhao, Y., Yang, L. and Tripp, R.A., 2016. Visible-light-activated bactericidal functions of carbon “Quantum” dots. ACS applied materials & interfaces, 8(17), pp.10761-10766. https://doi.org/10.1021/acsami.6b01765
• Wang, S., LeCroy, G.E., Yang, F., Dong, X., Sun, Y.P. and Yang, L., 2015. Carbon nanotube-assisted capturing of bacterial pathogens. RSC advances, 5(111), pp.91246-91253. https://doi.org/10.1039/C5RA16684E

Presentations

Oral Presentations

• Comprehensive integration of CTCF binding across cell types for cancer genomics and epigenetics research, Commonwealth of Virginia Cancer Research Conference, Richmond, VA, 2025
• Spatially clustered pattern of transcription factor binding reveals phase-separated transcriptional condensates at super-enhancers, invited speaker, 5th Annual Emerging Scholars in Genome Sciences Symposium 2024, University of Virginia, Charlottesville, VA, 2024
• Integration analysis of lncRNAs and R-loops in 3D genome organization and gene regulation in the cancer genome, 2024 Postdoctoral Research Symposium, University of Virginia, Charlottesville, VA, 2024

Poster Presentations

• Transcriptional condensates at super-enhancers mediate pH-dependent transcriptional regulation in innate immunity and human cancer, Cold Spring Harbor Laboratory Meeting on Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbor, NY, 2026
• CTCFDB: a systematic framework and comprehensive data resource for CTCF binding in the human genome, AACR Annual Meeting, Chicago, IL, 2025
• An integrated data resource and comprehensive data-driven approach to study CTCF binding in the human genome, RNA Center Inaugural Retreat, University of Virginia, Charlottesville, VA, 2025
• Spatially clustered pattern of transcription factor binding reveals phase-separated transcriptional condensates at super-enhancers, NIH NCI Histone Modifications and Chromatin Structure Symposium, National Institutes of Health, Bethesda, MD, 2024
• Integration analysis of lncRNAs and R-loops in 3D genome organization and gene regulation in the cancer genome, AACR Annual Meeting, San Diego, CA, 2024
• Roles of lncRNAs and R-loops in 3D genome organization and gene regulation in the cancer genome, BMG Annual Retreat, University of Virginia, Charlottesville, VA, 2022
• Analysis of topological properties of cancer-causing synonymous mutations, Frontiers of Computing in Health and Society, George Mason University, Virtually, 2021
• ValgusHel: A novel method to identify and characterize kinked alpha-helices, The Protein Society - 35th Anniversary Symposium, Virtually, 2021
• Structural and topological variations in amino acid residues encoded by synonymous codons, AAAS Annual Meeting, Washington D.C., 2019
• Investigation of polymer-functionalized carbon nanotube-coated filters for removal of bacterial pathogens, Institute of Biological Engineering Annual Conference, Greenville, SC, 2016

Scholarships, Awards and Honors

Journal Reviews

Reviewer: Cancer Research, Nucleic Acid Research

Ad hoc reviewer: Nature Cancer, Bioinformatics, Genome Biology

Mentoring Experience

Certificates